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Nat Rev Immunol (2011) 11(11):73849

COA documentation includes all analytical testing results

Application : Injection Sites : Common sites for SC injections include the abdomen (avoiding a 2-inch radius around the navel), the outer area of the upper arm, and the thigh

Albeit, such macrophage ablation studies must be interpreted with caution, as in a recent study, the anti-inflammatory effects of clodronate liposomes in arthritis models were attributed to the modulation of neutrophil effector functions after phagocytosis of liposomes (103)

The approach is always clinical: labs first, protocol second, monitoring ongoing